Doctordle Today: Daily Medical Diagnosis Puzzle

Diagnosis

Sjögren Syndrome / Sjogren Syndrome

Sjögren's Syndrome is a chronic systemic autoimmune disease characterized by immune-mediated destruction of exocrine glands. It is caused by lymphocytic infiltration and subsequent damage to glandular tissue, primarily salivary and lacrimal glands. Common symptoms include dry eyes (xerophthalmia), dry mouth (xerostomia), fatigue, and arthralgias. Workup includes anti-Ro (SSA) and anti-La (SSB) antibodies, Schirmer test, and minor salivary gland biopsy. Treatment involves symptomatic management with artificial tears/saliva, cholinergic agonists (pilocarpine, cevimeline), and immunosuppression for systemic manifestations.

Full clinical clue sequence

1. A 45-year-old woman presents with concerns of intermittent blurry vision.
2. She describes a gritty sensation in her eyes that has been present for several months.
3. She has a history of well-controlled rheumatoid arthritis.
4. Further questioning reveals she has frequent dental cavities despite good oral hygiene.
5. Physical exam reveals bilateral parotid gland enlargement and mild conjunctival injection.
6. Schirmer testing reveals reduced tear production. Serum testing is positive for anti-Ro and anti-La antibodies.